The Battlefield of Pluripotency
نویسنده
چکیده
How embryonic stem cells maintain the potential to differentiate into multiple cell lineages is still unclear. In this issue of Cell, Niwa et al. (2005) show that a duel between the transcription factors Oct3/4 and Cdx2 can restrict embryonic stem cells to either embryonic or placental fate. The vulnerability of lineage potential to transcriptional perturbation may reflect an essential feature of pluripotency.
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ورودعنوان ژورنال:
- Cell
دوره 123 شماره
صفحات -
تاریخ انتشار 2005